Huzoor Akbar, Ph.D.
Associate Professor Emeritus of Pharmacology
Department of Biomedical Sciences
akbar@ohio.edu
416 Irvine Hall
740-593-2406
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DEPT. OF BIOMEDICAL SCIENCES
DEPT. OF BIOLOGICAL SCIENCES
MOLECULAR & CELLULAR BIOLOGY PROGRAM
EDISON BIOTECHNOLOGY INSTITUTE
COLLEGE OF OSTEOPTHIC MEDICINE
 
 
Publications: Research Articles

Duan X., Perveen R., Dandamudi A., Adili R., Johnson J., Funk K., Berryman M, Davis AK., Holinstat M., Zheng Y. and Huzoor Akbar Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity specific inhibitor prevents platelet activation and thrombosis. Sci Rep 11, 13170 (2021)

Huzoor Akbar, X. Duan, R. Piatt, S. Saleem, A. K. Davis, N.N. Tandon, W. Bergmeier and Y. Zheng. Small molecule targeting the Rac1-NOX2 interaction prevents CRP and thrombin induced ROS generation and platelet activation. J Thromb Haemost 16, 2083-2096 (2018)


Hegde S., Huzoor Akbar, Zheng Y. and Cancelas J.A. Towards increasing shelf life and hemostatic potency of stored platelet concentrates. Current Opinion in Hematology 25, 500-508 (2018)

Huzoor Akbar, Xin Duan, Saima Saleem, Ashley K. Davis, Yi Zheng. RhoA and Rac1 GTPases differentially regulate agonist-receptor mediated reactive oxygen species generation in platelets. PLoS ONE 11(9): e0163227. doi:10.1371/journal. pone.0163227 (2016)

Huzoor Akbar. Antithrombotic drugs and their complications. DOI: 10.1016/B978-0-12-386456-7.0719-4. In Pathobiology of Human Disease, Publisher: Elsevier, Editors: Linda M. McManus, Richard N. Mitchell, pp.1613-1627 (2014)

Liu Y., Cao Y., Zhang W., Bergmeier S., Qian Y., Huzoor Akbar., Colvin R., Ding J., Tong L., Wu S., Hines J., Chen X. A small molecule inhibitor of glucose transporter 1 down-regulates glycolysis, induces cell cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol Cancer Ther. 11, 1672 (2012)


Perveen, R., Funk, K., Ridge, S.W., Cao, Y., Akkerman, J.A.W., Chen, X. and Huzoor Akbar. A novel small molecule 1,2,3,4,6 penta-O-galloyl-α-D-glucopyranose mimics the antiplatelet actions of insulin. PLoS ONE 6(11): e26238 (2011)


Huzoor Akbar, Shang, X., Perveen, R., Berryman, M., Funk, K., Johnson, J.F., Tandon, N.N. and Zheng, Y. Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation. PLoS One 6(7):e22117 (2011)

Huzoor-Akbar, Kim, J., Funk, K., Cancelas, J. A., Shang, X., Chen, L., Johnson, J. F., Williams, D. A. and Zheng, Y.: Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation. J. Thromb and Haemost 5, 1747-1755 (2007)

Huzoor-Akbar, Cancelas, J. A., Williams, D. A., Zheng, J. and Zheng, Y. Rational design and applications of a Rac GTPase-specific small molecule inhibitor. Methods Enzymology 406, 554-565 (2006)


Huzoor-Akbar Biochemistry of altered platelet reactivity in hypertension In: Platelet Physiology and Pharmacology. Ed. G. H. R. Rao. Kluwer Academic Publishers, Norwell, MA, 439-457 (1999)

Gerstmann, P. A., Segerson, Jr. E.C, Huzoor-Akbar and Murray, F. A. Purification of porcine uterine retinol-binding proteins and their effect on platelet aggregation. WWW J. Biol. Vol 2, Article 5 (1996)


Agarwal, K.C., Clarke, E., Rounds, S., Parks Jr., R. E. and Huzoor-Akbar Platelet-Activating Factor-induced platelet aggregation: Modulation by plasma adenosine and methylxanthines. Biochemical Pharmacology 48, 1909-1916 (1994)


Huzoor-Akbar, Wang, W., Kornhauser, R., Volker, C. and Stock, J. Protein prenylcysteine analog inhibits agonist-receptor mediated signal transduction in human platelets. Proc. Natl. Acad. Sci. USA. 90, 868-872 (1993)


Huzoor-Akbar, Dean, T. and Kornhauser, R. Increased platelet reactivity to prostaglandin E1 in hypertension is linked with altered signal transduction. Am. J. Hypertension 6, 857-862 (1993)


Huzoor-Akbar, Kundu, N. and Kornhauser, R. Normal thrombin binding leads to greater fibrinogen binding and increased platelet aggregation in Spontaneously Hypertensive Rats. Life Sciences 53, 1967-1974 (1993)

Huzoor Akbar. Role of protein methylation in agonist-induced signal transduction in human platelets. SAAS Bull Biochem Biotechnol 5, 7-12 (1992) PMID: 1368183


Huzoor-Akbar, Winegar, D.A. and Lapetina, E.G. Carboxyl methylation of platelet rap1 proteins is stimulated by Guanosine 5'-(3-O-Thio) trisphosphate. J. Biol. Chem. 266, 4387-4391 (1991)

Romstedt, K.J. and Huzoor-Akbar: Lipoprotein-platelet interactions and antilipidemic drugs. In: Antilipidemic Drugs: Medicinal Chemical and Biochemical Aspects. Witiak, D.T., Newman, H.A.I. and Feller, D.R. (Ed), Elsevier, Amsterdam, The Netherlands (1991). P. 427-453.

Huzoor-Akbar, Chen, N.Y., Fossen, D.V. and Wallace, D. Increased vascular contractile sensitivity to serotonin in spontaneously hypertensive rats is linked with increased turnover of phosphoinositide. Life Sci. 45, 577-83 (1989)


Anwer, K., Wallace, D., Romstedt, K. and Huzoor-Akbar. Human platelet activation by bacterial phospholipase C: mechanism of inhibition by flurazepam. Thromb Res. 49, 225-39 (1988)


Huzoor-Akbar and Anwer, K. Thrombin-induced abnormal platelet activation in spontaneously hypertensive rats is linked with phosphoinositides turnover and phosphorylation of 47,000 and 20,000 Dalton proteins. Thromb Res. 49, 5-21 (1988)


Timmons, S., Huzoor-Akbar, Grabarek, J., Kloczewiak, M. and Hawiger, J. Mechanism of human platelet activation by endotoxic glycolipid-bearing mutant Re595 of Salmonella minnesota. Blood 68, 1015-23 (1986)


Huzoor-Akbar and Anwer, K. Evidence that the rat is not an appropriate model to study the role of prostaglandins in normal or abnormal platelet aggregation. Thromb Res. 41, 555-66 (1986)


Clark, M.T., Chang, J., Navran, S.S., Huzoor-Akbar, Mukhopadhyay, A., Amin, H., Feller, D.R. and Miller, D.D. Synthesis and investigation of the beta-adrenoceptor agonist and platelet antiaggregatory properties of 1,7,8-trisubstituted 2,3,4,5-tetrahydro-1H-2-benzazepine analogues of trimetoquinol. J Med Chem. 29, 181-5 (1986)


Anwer, K., Gabis, J., Romstedt, K., Gojer, C. and Huzoor-Akbar. Beclobrinic acid - a new hypolipidemic agent - inhibits in vitro human platelet activation by blocking prostaglandin synthesis. Life Sci. 37, 63-70 (1985)


Romstedt, K. and Huzoor-Akbar. Benzodiazepines inhibit human platelet activation: comparison of the mechanism of antiplatelet actions of flurazepam and diazepam. Thromb Res. 38, 361-74 (1985)


Huzoor-Akbar, Mukhopadhyay, A., Anderson, K.S., Navran, S.S., Romstedt, K., Miller, D.D. and Feller, D.R. Antagonism of prostaglandin-mediated responses in platelets and vascular smooth muscle by 13-azaprostanoic acid analogs. Evidence for selective blockade of thromboxane A2 responses. Biochem Pharmacol. 34, 641-7 (1985)


Huzoor-Akbar and Romstedt, K. 3-Deazaadenosine and L-homocysteine inhibit human platelet activation induced by arachidonic acid, U46619 and phospholipase C. Thromb Res. 36, 369-76 (1984)


Navran, S.S., Romstedt, K., Chang, J., Miller, D.D., Feller, D.R. and Huzoor-Akbar. Human platelet activation by bacterial phospholipase C is mediated by phosphatidylinositol hydrolysis but not generation of phosphatidic acid: inhibition by a selective inhibitor of phospholipase C. Thromb Res. 33, 499-510 (1984)


Huzoor-Akbar, Romstedt, K., and Manhire, B. Computerized aggregation instruments: a highly efficient and versatile system for acquisition, quantitation, presentation and management of platelet aggregation data. Thromb Res. 32, 335-41 (1983)


Huzoor-Akbar, Witiak, D.T., Newman, H.A., Fertel, R.H. and Feller, D.R. Potentiating effects of clofibrate on prostaglandin-dependent and -independent pathways of human platelet activation: evidence for involvement of cyclic AMP. Biochem Pharmacol. 31, 2125-8 (1982)


Witiak, D.T., Kokrady, S.S., Patel, S.T., Huzoor-Akbar, Feller, D.R. and Newmann, H.A. Hypocholesterolemic and antiaggregatory properties of 2-hydroxytetronic acid redox analogues and their relationship to clofibric acid. J Med Chem. 25, 90-3 (1982)


Mayo, J.R. Navran, S.S., Huzoor-Akbar, Miller, D.D. and Feller, D.R. Stereo-dependent inhibition of human platelet function by the optical isomers of trimetoquinol. Biochem Pharmacol. 30, 2237-41 (1981)


Huzoor-Akbar, Patel, S., Kokrady, S.S., Witiak, D.T., Newman, H.A. and Feller D.R. Effects of clofibrate and 6-substituted chroman analogs on human platelet function: mechanism of inhibitory action. Biochem Pharmacol. 30, 2013-20 (1981)


Huzoor-Akbar and Ardlie, N.G. Investigation of the role of arachidonic acid in platelet function and mechanisms for suppression of prostaglandin biosynthesis. Br J Haematol. 39, 71-81 (1978)


Huzoor-Akbar and Ardlie, N.G. Further evidence for the role of thrombin in the platelet release reaction caused by various agents, and the nature of biphasic platelet aggregation. Br J Haematol. 38, 381-90 (1978)


Huzoor-Akbar, Afroz, H., Ali, S.S. Effects of adrenaline on blood sugar and plasma lipid levels of a hibernating lizard during active and hibernation period. Comp Biochem Physiol C. 60, 205-9 (1978)


Huzoor-Akbar and Ardlie, N.G. The effect of halofenate--free acid on aggregation, the release reaction, coagulant activity, and lipid metabolism of human platelets. Thromb Haemost. 38, 612-9 (1977)


Huzoor-Akbar and Ardlie NG. Platelet activation in haemostasis: role of thrombin and other clotting factors in platelet-collagen interaction. Haemostasis. 6, 59-71 (1977)


Huzoor-Akbar and Ardlie, N.G. Effects of clofibrate on platelets and evidence of the involvement of platelet lipids in platelet function. Thromb Res. 10, 95-105 (1977)


Huzoor-Akbar and Ardlie, N.G. Evidence that collagen releases human platelet constituents by two different mechanisms. Br J Haematol. 34, 137-46 (1976)

Publications: Research Abstracts

Dandamudi A., Seibel W., Huzoor Akbar and Zheng Y. Structure-activity relationship analysis of analogs of Rhosin, a RhoA Inhibitor, reveals a new generation of improved antiplatelet agents. Proceedings of the 63rd American Society of Hematology meeting (2021)

RhoA targeting suppresses cold-induced platelet lesion and allows refrigerated storage of functional human platelets to fourteen days. Hegde S., Huzoor Akbar, Nestheide S., Wellendorf AW., Bohan B., Johnson JF., Zheng Y., Cancelas, JA. Blood 134 (Suppl1): 99 (2019)

NOX2 as an anti-thrombosis target: small molecule targeting of Rac1-p67phox signaling prevents NOX2 mediated GPVI- and non-GPVI dependent ROS generation and platelet activation. Huzoor Akbar, Xin Duan, Saima Saleem, Ashley K. Davis and Yi Zheng. XXVI Congress of the international Society on Thrombosis and Haemostasis. Research and Practice in Thrombosis and Haemostasis OC 30.1, 235-236 (2017)

Reversible pharmacological targeting of RhoA allows improved storage, survival and hemostatic activity of platelets in vitro and in vivo, in mice and in primates. Shailaja Hegde, Huzoor Akbar, Shawnagay Nestheide, Ashley Wellendorf, Fatima Mohmoud, James Johnson, Yi Zheng, Jose Cancelas. European Hematology Association, Presidential Symposium S149 (2017)

S Hegde, Huzoor Akbar, S Nestheide, A Wellendorf, F Mohmoud, J Johnson, Y Zheng, J Cancelas. Reversible pharmacological targeting of RhoA prevents refrigerated platelet storage lesion and restores normal platelet survival. Transfusion 56(S4); 230A (AP30), (2016)

Huzoor Akbar, Xin Duan, Saima Saleem, Ashley K. Davis and Yi Zheng. Differential signaling by CRP-Rac1-NOX1 and thrombin-Rac1-NOX2 axes regulates ROS generation and platelet activation. The American Heart Association (Proceedings 16th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology (May 2015).

Huzoor Akbar, Xin Duan, Saima Saleem, Ashley K. Davis and Yi Zheng. RhoA and Rac1 GTPases differentially regulate agonist-receptor mediated ROS generation in platelets. Proceedings of the 56th American Society of Hematology meeting (December 2014).

Huzoor Akbar, Saima Saleem, Ashley Kuenzi, and Yi Zheng.: NADPH oxidase (NOX) isoforms NOX1 and NOX2 differentially regulate GPVI- and non-GPVI-dependent ROS generation and platelet activation. The American Heart Association (Proceedings 15th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology (2014).

Huzoor Akbar, Saima Saleem, Ashley Kuenzi, and Yi Zheng.: RhoA GTPase regulates reactive oxygen species mediated platelet activation. The American Heart Association (Proceedings 15th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology (2014).

Huzoor Akbar, Saima Saleem, Ashley Kuenzi, and Yi Zheng.: Rational targeting of Rac-NOX2 pathway prevents ROS generation and platelet activation involving MLC, Akt and Ca++-PKC signaling induced by diverse agonists. J Thromb Haemost 11(S2) 345 (2013).

Huzoor-Akbar, Shang, X., Perveen, R., Funk, K. and Yi Zheng.: Specific pharmacologic targeting of Rho GTPases Rac1, Cdc42 and RhoA reveals their differential and critical roles in regulation of platelet activation. Blood 116(21): 841(2010).

Huzoor-Akbar, Funk, K., Berryman, M., Raines, J., Perveen, R., Shang, X., and Yi Zheng.: Genetic and pharmacologic evidence shows that Cdc42 GTPase plays a central role in regulation of both GP VI- and non-GP VI-dependent activation of platelets. Blood 114(22): 1169(2009).

Huzoor-Akbar, Funk, K, Perveen, R, Shang, X, and Zheng, Y.: Rho GTPases Rac1 and RhoA differentially regulate platelet actin reorganization, secretion and aggregation. J Thromb Haemost 7: s2 310 (2009).

Huzoor-Akbar, Funk, K, Wulf, S, Perveen, R, Cao, Y, Chen, X.: Anti-diabetic small molecule 1, 2, 3, 4, 6-penta-O-galloyl-
a-D-glucopyranose inhibits platelet activation by preventing Gia2-mediated signal transduction. J Thromb Haemost 7 s2: 649 (2009).

Huzoor-Akbar, Berryman, M, Funk, K, Perveen, R, Shang, X, and Zheng, Y.: Genetic and pharmacologic targeting of Cdc42 GTPase reveals its critical role in regulation of platelet activation. Circulation 118: S_408 (2008).

Huzoor-Akbar, Raines, J, Funk, K, Berryman, M, Shang, X, and Zheng, Y.: Essential role of the Rho GTPase Cdc42 in platelet adhesion, spreading, secretion and aggregation revealed by a novel Cdc42-activity specific inhibitor. FEBS Journal 275 (Suppl. 1) 328 (2008).

Huzoor-Akbar, Cancelas, JA, Wang, L., Chen, L., Williams, DA and Zheng, Y.: Pharmacological targeting of Rac1 GTPase in platelets: A novel approach for developing antithrombotic agents. Circulation 114, II-250 (2006)

Huzoor-Akbar, Cancelas, JA, Johnson, JF, Lee, AW, Williams, DA and Zheng, Y.: Genetic and pharmacological evidence that RAC1 GTPase is a novel anti-platelet agent. Proceedings 7th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology (2006)

Huzoor-Akbar, Wang, L, Chen, L, Johnson, JF, Williams, DA and Zheng, Y.: Gene targeting or pharmacological inhibition of Rac GTPases prolongs the bleeding time and reduces platelet adhesion, secretion and aggregation: Evidence for the Rac-mediated activation of MAP kinases during platelet activation. J. Thromb. Haemost. 3, S1 (2005)

Huzoor-Akbar, Jensen, BO, Holmsen, H.: Phosphorylation of platelet rap 1b by nitric oxide inhibits platelet aggregation. Proceedings: Cellular Regulation by Protein Phosphorylation (1997)

Huzoor-Akbar: Role of nitric oxide/cyclic GMP signaling mechanisms in increased platelet sensitivity to thrombin in hypertension. FASEB J 9, A922 (1995)

Huzoor-Akbar, Calub, F., Jensen, BO, Holmsen, H.: Nitric oxide-induced phosphorylation of platelet rap 1b serves as one of the signals for inhibition of platelet aggregation. Canadian J. Physiol. Pharmacol. 72, 479 (1994)

Huzoor-Akbar: Mechanisms Involved in Altered Platelet Reactivity to Thrombin, Prostaglandin E1 and Nitric Oxide in Hypertension. Proceedings of the SASAT Symposium. A55 (1994)

Kornhauser, R. and Huzoor-Akbar: Thrombin-receptor activated peptide and GTPgS induce human platelet activation but fail to stimulate rat platelets. Thrombosis Haemostasis 69, 1195 (1993)

Huzoor-Akbar, Kundu, N. and Kornhauser, R.: Thrombin-induced increased platelet aggregation in hypertension: Evidence that normal thrombin binding leads to increased signal transduction and greater fibrinogen binding. Thrombosis Haemostasis 69, 1342 (1993)

Huzoor-Akbar, Dean, T. and Kornhauser, R.: Increased platelet reactivity to prostaglandin E1 in hypertension is linked with altered signal transduction. Thrombosis Haemostasis 69, 1343 (1993)

Agarwal, K. C., Huzoor-Akbar and Parks, R. E. Jr.: Vasopressin-induced intracellular calcium mobilization in human platelets: Blockade by adenosine. Thrombosis Haemostasis 69, 1243 (1993)

Huzoor-Akbar and Kornhauser, R.: Increased platelet reactivity in hypertension is linked with altered signal transduction. Proc. 4th Erfurt Conference on Platelets, p.9 (1992)

Huzoor-Akbar, Kornhauser, R., Stock, J. and Wang, W.: Mechanisms of the antiplatelet actions of N-acetyl-S-farnesyl-l-cysteine, a competitive inhibitor of the carboxyl methyl transferase. Proc. 4th Erfurt Conference on Platelets, p.49 (1992)

Huzoor-Akbar, Stock, J.B. and Wang, W.: N-Acetyl-S-farnesyl-cysteine, a competitive inhibitor of the carboxyl methyltransferase, inhibits agonist-receptor- but not phorbol ester- or phospholipase C-induced platelet activation. FASEB J. 6, A1598 (1992)

Kundu, N. and Huzoor-Akbar: Inositol trisphosphate generation and mobilization of calcium is increased in platelets from spontaneously hypertensive rats. FASEB J. 5, A899 (1991)

Huzoor-Akbar, Winegar, D.A. and Lapetina, E.G.: Carboxyl methylation of platelet rap1 proteins is stimulated by GTPgS. FASEB J. 5, A1205 (1991).

Gerstmann, P.A., Huzoor-Akbar, Segerson, E. and Murray, F.A.: Porcine uterine secretory proteins inhibit early signal transduction events in human platelet activation. Prostaglandins, Leukotrienes, Lipoxins & PAF. Proc. XIth Washington International Spring Symposium 284, (1991)

Huzoor-Akbar and Kundu, N.: Mobilization of intra- and extracellular calcium, but not the basal calcium level, is increased in platelets from spontaneously hypertensive rats. Proc. 20th FEBS Meeting p. 150 (1990)

Gerstmann, P.A., Murray, F.A. and Huzoor-Akbar: Porcine uterine secretory proteins inhibit human platelet activation mediated by a prostaglandin-independent mechanism. FASEB J. 4, A1776 (1990)

Kundu, N. and Huzoor-Akbar: Flurazepam inhibits agonist-induced, inositol trisphosphate- and prostaglandin-mediated but not the direct, increase in human platelet ionized calcium. Thrombosis Haemostasis 62, 48 (1989)

Huzoor-Akbar, Anwer, K. and Kundu, N.: Platelet activation by bacterial phospholipase C involves hydrolysis of phosphoinositide, rise in ionized calcium and phosphorylation of 47 kD but not 20 kD protein. Thrombosis Haemostasis 62, 103 (1989)

Huzoor-Akbar, Anwer, K. and Kundu, N.: mechanisms of thrombin-induced abnormal platelet aggregation in spontaneously hypertensive rats. Thrombosis Haemostasis 62, 423 (1989)

Huzoor-Akbar, Anwer, K., Wince, L. and Kundu, N.: Platelet phospholipid metabolism and fatty acid composition, but not the cholesterol/ phospholipid ratio, is altered in spontaneously hypertensive rats. FASEB J. 3, A 311 (1989)

Huzoor-Akbar, Chen, N. Y., Wallace, D. and Van Fossen, D.: Serotonin-induced abnormal vascular contraction in spontaneously hypertensive rats is linked with increased phosphoinositides turnover. FASEB J. 2, A 1786 (1988)

Kundu, N. and Huzoor-Akbar: Flurazepam inhibits bacterial phospholipase C- and thrombin-induced but not ionomycin-induced increase in human platelet ionized calcium. FASEB J. 2, A399 (1988)

Huzoor-Akbar and Anwer, K.: Evidence that abnormal platelet aggregation in spontaneously hypertensive rats is linked with phosphoinositides turnover and phosphorylation of 47,000 Dalton protein. Thrombosis Haemostasis 58, 275 (1987)

Huzoor-Akbar, Wallace, D. and Anwer, K.: Human platelet activation by bacterial phospholipase C: Mechanism of inhibition by flurazepam. Thrombosis Haemostasis 58, 175 (1987)

Huzoor-Akbar and Anwer, K: Phosphorylation of the 47kD protein and phosphoinositides turnover is involved in abnormal platelet activation in spontaneously hypertensive rats. Adv. Cyclic Nucleotides Protein Phosphorylation Res. (1987)

Huzoor-Akbar and Anwer, K.: Platelet activation by bacterial PLC involves phosphoinositide turnover and phosphorylation of 47kD protein. Fed. Proc. 45, 1566 (1986)

Anwer, K. and Huzoor-Akbar: Abnormal platelet aggregation in spontaneously hypertensive rats is linked with phosphoinositide turnover but not prostaglandin synthesis. Fed. Proc. 45, 226, (1986)

Huzoor-Akbar and Anwer, K.: Evidence that prostaglandins are not involved in platelet aggregation in normotensive and hypertensive rats. J.A.O.A. 86, 154 (1986)

Clark, M.T., Chang, J., Navaran, S.S., Huzoor-Akbar, Mukhopadhyay, A., Amin, H., Feller, D.R. and Miller, D.D.: Synthesis and biological activity of 1,7,8-Trisubstituted-2,3,4,5-tetrahydro-1H-2-benzazepine analogs of trimetoquinal. Pharmacologist 27, 155, (1985).

Huzoor-Akbar and Anwer, K.: Evidence that the rat is not an appropriate model to study the role of prostaglandins in normal or abnormal platelet aggregation. Thrombosis Haemostasis 54, 244, (1985)

Anwer, K., Romstedt, K. and Huzoor-Akbar: Characterization of a prostaglandin independent mechanism of stimulus response coupling in rat blood platelets. Fed. Proc. 44, 1644, (1985)

Romstedt, K. and Huzoor-Akbar: The effects and the mechanism of the antiplatelet action of flurazepam. Fed. Proc. 44, 1644, (1985)

Romstedt, K., Anwer, K. and Huzoor-Akbar: 3 deazaadenosine and L-homocysteine inhibit human platelet activation by arachidonic acid, U46619 and phospholipase C. Fed. Proc. 43, 976, (1984)

Huzoor-Akbar and Romstedt, K.: Diazepam inhibits human platelet function: evidence for multiple sites of action. J.A.O.A. 84, 220, (1984)

Huzoor-Akbar, Romstedt, K., Anderson, K., Mukhopadhyay, A., Miller, D.D. and Feller, D.R.: Antagonism of prostaglandin-mediated responses in platelets and vascular smooth muscle by 13-azaprostanoic acids. Pharmacologist 25, 204, (1983)

Huzoor-Akbar, Romstedt, K. and Manhire, B.: Platelet aggregometer interfaced to a microcomputer: A highly efficient and versatile system for acquisition, quantitation, presentation and management of aggregation data. Fed. Proc. 42, 1029, (1983)

Romstedt, K., Gabis, J. and Huzoor-Akbar: Evidence that beclobrinic acid, a new hypolipidemic agent, inhibits human platelet function. J.A.O.A. 83, 179, (1983)

Huzoor-Akbar, Navran, S.S., Chang, J., Miller, D.D. and Feller, D.R.: Evidence that activation of human platelets by phospholipase C depends on phosphatidylinositol hydrolysis but not generation of prostaglandins, release of ADP or platelet activating factor. Proc. Int. Cong. Haematol. 337, (1982)

Navran, S.S., Huzoor-Akbar, Chang, J., Miller, D.D. and Feller, D.R.: Exogenous phospholipase C stimulates aggregation and phosphatidylinositol breakdown in human platelets: Inhibition by trimetoquinol and a benzazepine analog. Fed. Proc. 41, 1120, (1982)

Huzoor-Akbar, Navran, S., Chang, J., Miller, D. and Feller, D.R.: Effects of trimetoquinol and related benzazepine analogs on aggregation; serotonin uptake and secretion by human platelets. Physiologist 29, 86, (1981)

Huzoor-Akbar, Kokrady, S.S., Newman, H.A.I., Witiak, D.T. and Feller, D.R.: Effects of 4-(4'-cholorphenyl)-2-hydroxy-tetronic acid and related analogs on human platelet aggregation and serotonin secretion. Clin. Res. 29, 717A, (1981)

Feller, D.R., Navran, S.S., Mayo, J.R., Miller, D.D. and Huzoor-Akbar: Differential stereoselective inhibition by trimetoquinol of platelet aggregation mediated by prostaglandin dependent and independent pathways. VIIIth International Congress of Pharmacology Abstract #1192 (1981)

Huzoor-Akbar, Feller, D.R.: Insight into the phospholipase C-mediated pathway of human platelet activation. Fed. Proc. 40, 808 (1981)

Brown, J.A., Huzoor-Akbar and Hawiger, J.: Prostacyclin protects human platelets from endotoxin-mediated injury by Gram negative bacteria. Clin. Res. 28, 510 (1980).

Huzoor-Akbar, Patel, S., Kokrady, S.S., Witiak, D.T., Newman, H.A.I. and Feller, D.R.: Effects of clofibrate and related analogs on human platelet function: Mechanisms of inhibitory action. Fed. Proc. 39, 543 (1980)

Feller, D.R., Newman, H.A.I., Witiak, D.T., Fertel, R.H. and Huzoor-Akbar: Clofibrate promotes platelet aggregation and secretion induced by arachidonic acid and phospholipase C. Clin. Res. 28, 310A (1980)

Huzoor-Akbar, Newman, H.A.I., Witiak, D.T. and Feller, D.R.: Clofibric acid inhibits phospholipase A2 mediated but enhances phospholipase C-induced activation of human blood platelets. Clin. Res. 27, 636A (1979)

Huzoor-Akbar, Timmons, S. and Hawiger, J.: Human platelet injury by endotoxin-producing bacteria: Cell wall determinants of platelet activating mechanism. Clin. Res. 36, 388A (1978)

Ardlie, N.G. and Huzoor-Akbar: Further evidence of the involvement of thrombin in platelet release by ADP and other agents. Thrombosis Haemostasis 38, 36 (1977)

Huzoor-Akbar and Ardlie, N.G.: Essential role of thrombin in platelet-collagen interaction. Clin. Exptl. Pharmacol. Physiol. 4, 495 (1977)

Huzoor-Akbar and Ardlie, N.G.: Halofenate -- a tool for evaluating the role of platelet lipids in platelet function. Clin. Exptl. Pharmacol. Physiol. 4, 495 (1977)

Ardlie, N.G. and Huzoor-Akbar: Evidence that collagen releases human platelet constituents by two different mechanisms. Clin. Exptl. Pharmacol. Physiol. 3, 285 (1976)

Huzoor-Akbar and Ardlie, N.G.: Effect of clofibrate on platelet aggregation, coagulant activity and incorporation of 14C-acetate into platelet lipids. Clin. Exptl. Pharmacol. Physiol. 3, 284 (1976)

   
   
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Last updated: 11/16/2021