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Huzoor
Akbar, Ph.D.
Associate Professor Emeritus of Pharmacology
Department of Biomedical Sciences
akbar@ohio.edu
416 Irvine Hall
740-593-2406 |
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Pharmacologic targeting of Cdc42
GTPase by a small molecule Cdc42 activity specific
inhibitor prevents platelet activation and
thrombosis. Sci Rep 11, 13170 (2021)
https://www.nature.com/articles/s41598-021-92654-6
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Pharmacologic targeting of Rac1-NOX2 axis by Phox-I,
a small molecule inhibitor of the Rac1-p67phox
interaction inhibits in vivo thrombus formation
without affecting the hemostasis. (J Thromb
Haemost 2018; 16: 2083–96) |
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Pharmacologic targeting of RhoA by Rhosin or gene
targeting of RhoA prevents platelet spreading on
immobilized fibrinogen. (PLoS ONE 11(9): e0163227) |
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| Gene
targeting of Cdc42 GTPase inhibits filopodia and
lamellipodia formation on immobilized
collagen-related peptide. (PLoS ONE 6(7): e22117) |
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