Huzoor Akbar, Ph.D.
Associate Professor Emeritus of Pharmacology
Department of Biomedical Sciences
akbar@ohio.edu
416 Irvine Hall
740-593-2406
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DEPT. OF BIOMEDICAL SCIENCES
DEPT. OF BIOLOGICAL SCIENCES
MOLECULAR & CELLULAR BIOLOGY PROGRAM
EDISON BIOTECHNOLOGY INSTITUTE
COLLEGE OF OSTEOPTHIC MEDICINE
 

 

Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity specific inhibitor prevents platelet activation and thrombosis. Sci Rep 11, 13170 (2021) https://www.nature.com/articles/s41598-021-92654-6

 
Pharmacologic targeting of Rac1-NOX2 axis by Phox-I, a small molecule inhibitor of the Rac1-p67phox interaction inhibits in vivo thrombus formation without affecting the hemostasis. (J Thromb Haemost 2018; 16: 208396)  
   
   
 
Pharmacologic targeting of RhoA by Rhosin or gene targeting of RhoA prevents platelet spreading on immobilized fibrinogen. (PLoS ONE 11(9): e0163227)  
   
   

 
Gene targeting of Cdc42 GTPase inhibits filopodia and lamellipodia formation on immobilized collagen-related peptide. (PLoS ONE 6(7): e22117)  
   
   
  Ohio University
Heritage College of Osteopathic Medicine
Irvine Hall, Athens, Ohio 45701
740-593-2530 740-597-2778 fax
 
Last updated: 11/16/2021